Developing Herbal Antidote or Method of Combact Poisoning

Need for antidote for aluminium phosphide poisoning.

Human toxicity of aluminium phosphide occurs due to the toxic effects of phosphine which is liberated in stomach on ingestion (1). The effect is worse in the presence of hydrochloric acid in the stomach. It is widely absorbed from gastrointestinal tract and has cytotoxic action as it inhibits mitochondrial respiration. It affects almost all systems i.e. gastrointestinal, cardiovascular, respira...

Evaluation of oxime k203 as antidote in tabun poisoning.

We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. We compared it with oximes K048 and TMB-4, which have proven the most efficient oxime antidotes in tabun poiso...

Ayurvedic herbal supplements as an antidote to 9/11 toxicity.

An in-treatment web-based survey was conducted in 2005 with 50 New York World Trade Center rescue and recovery workers, volunteers, and area residents and workers who were treated with Ayurvedic herbs for post-9/11 symptoms. The survey documented pretreatment efforts at symptom relief, post-treatment symptom impact, and the context for using the herbal intervention. Herbal treatment was adminis...

N-acetylcysteine as an antidote in methylmercury poisoning.

Methylmercury is a ubiquitous environmental pollutant and potent neurotoxin. Treatment of methylmercury poisoning relies almost exclusively on the use of chelating agents to accelerate excretion of the metal. The present study demonstrates that oral administration of N-acetylcysteine (NAC), a widely available and largely nontoxic amino acid derivative, produces a profound acceleration of urinar...

British anti-lewisite as an antidote for acute mercury poisoning.